Active substances from the Baltic sea
In close cooperation with the Institute of Pharmacy, Department of Pharmaceutical Biology of the Ernst-Moritz-Arndt-University Greifswald the researchers of the IMaB isolate microorganisms from the Baltic sea, especially cyanobacteria and marine fungi and establish laboratory cultures.
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Microscopic photograph of the cyanobacterium Limnothrix redekei HUB 051, 1000x |
Microscopic photograph of the spores of the marine fungus Corollospora maritima, 1000x |
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Laboratory cultures of cyanobacteria under continuous light |
Laboratory cultures of marine fungi on a shaker |
The organisms are cultivated in larger scale and extracts are prepared from the cultivation medium and the biomass.
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Cultivation of marine fungi in a fermenter under stirring |
Cultivation of a cyanobacterium in a 50-l fermenter |
The extracts are screened in different “in-vitro-test-systems” for antimicrobial, antiviral and immunomodulating activity. After this a bioassay-guided isolation process is used for isolation of the active compounds. The characterization and structural elucidation of the isolated substances is carried out.